Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity.

Cell2014Lee YS, Kim JW, Osborne O, et al.

Study designOther primary literature

SubjectAnimal

Abstract

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MeSH

Adenine Nucleotide Translocator 2AdipocytesAnimalsBasic Helix-Loop-Helix ProteinsCell HypoxiaDiet, High-FatEndothelial PAS Domain-Containing Protein 1Fatty AcidsHypoxia-Inducible Factor 1, alpha SubunitInflammationInsulin ResistanceLactic AcidMiceMice, KnockoutNitric OxideObesityOxygen

DOI 10.1016/j.cell.2014.05.012

PMID 24906151

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