Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation.
Molecular psychiatry2016Harraz MM, Tyagi R, Cortés P, et al.
Study designOther primary literature
SubjectHuman & animal
Abstract
cc by 以外（cc by-nc / cc by-nc-nd / NONE 等）は抄録を再掲しない。DOI/PMID へのリンクのみ表示する。
MeSH
AnimalsAntidepressive AgentsCells, CulturedCerebral CortexCysteineDepressionDisease Models, AnimalEmbryo, MammalianExploratory BehaviorFemaleGene Expression RegulationHEK293 CellsHumansKetamineMaleMice, Inbred C57BLMice, KnockoutMonomeric GTP-Binding ProteinsN-MethylaspartateNeuronsNeuropeptidesNitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IIPregnancyProteolysisRas Homolog Enriched in Brain ProteinS-NitrosothiolsSignal TransductionSwimmingTOR Serine-Threonine KinasesTime Factors