Spinal alpha(2)-adrenergic and muscarinic receptors and the NO release cascade mediate supraspinally produced effectiveness of gabapentin at decreasing mechanical hypersensitivity in mice after partial nerve injury.
British journal of pharmacology2006Takasu K, Honda M, Ono H, et al.
Study designOther primary literature
SubjectAnimal
Abstract
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MeSH
Adrenergic alpha-2 Receptor AntagonistsAminesAnalgesicsAnimalsAtropineCholinesterasesCyclohexanecarboxylic AcidsEnzyme ActivationGabapentinHot TemperatureHyperalgesiaIdazoxanInjections, IntraventricularMaleMiceMuscarinic AntagonistsNG-Nitroarginine Methyl EsterNarcotic AntagonistsNeostigmineNitric OxideNitric Oxide SynthaseReceptors, Adrenergic, alpha-2Receptors, MuscarinicSciatic NerveSpinal CordTouchYohimbinegamma-Aminobutyric Acidomega-N-Methylarginine