Oncogenic Kaposi's Sarcoma-Associated Herpesvirus Upregulates Argininosuccinate Synthase 1, a Rate-Limiting Enzyme of the Citrulline-Nitric Oxide Cycle, To Activate the STAT3 Pathway and Promote Growth Transformation.

Journal of virology2019Li T, Zhu Y, Cheng F, et al.

Study designOther primary literature

SubjectHuman & animal

Abstract

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MeSH

AnimalsArgininosuccinate SynthaseCarcinogenesisCell ProliferationCitrullineEndothelial CellsGene Expression Regulation, ViralGlutamineHEK293 CellsHerpesviridae InfectionsHerpesvirus 8, HumanHumansMetabolic Networks and PathwaysMicroRNAsNitric OxideNitrogenOncogenesPrimary Cell CultureRatsSTAT3 Transcription FactorSarcoma, KaposiSignal TransductionTranscriptional ActivationUp-Regulation

DOI 10.1128/jvi.01599-18

PMID 30463977

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