Integrative Network Toxicology, Machine Learning, Single-Cell Analysis, scTenifoldKnk-Based Virtual Knockout, and Molecular Docking Suggest a Potential Molecular Link Between Aspartame and Rheumatoid Arthritis Involving <i>HLA-DRB1</i>.

International journal of molecular sciences2026Yan T, He Q, Shi X

Study designOther primary literature

SubjectHuman

Abstract

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MeSH

Arthritis, RheumatoidAspartameGene Expression ProfilingGene Regulatory NetworksHLA-DRB1 ChainsHumansMachine LearningMolecular Docking SimulationSingle-Cell AnalysisSweetening Agents

DOI 10.3390/ijms27135798

PMID 42450069

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