Inducible nitric oxide synthase inhibition increases MMP-2 activity leading to imbalance between extracellular matrix deposition and degradation after polypropylene mesh implant.

Journal of biomedical materials research. Part A2013Souza-Pinto FJ, Moretti AI, Cury V, et al.

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MeSH

AnimalsEnzyme InhibitorsExtracellular MatrixInflammationInterleukin-1betaMaleMatrix Metalloproteinase 2MiceMice, Inbred C57BLNG-Nitroarginine Methyl EsterNitric OxideNitric Oxide Synthase Type IIPeritoneumPolypropylenesProstheses and ImplantsSurgical Mesh

DOI 10.1002/jbm.a.34440

PMID 23077110

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