CPT1A loss disrupts BCAA metabolism to confer therapeutic vulnerability in TP53-mutated liver cancer.
Cancer letters2024Liu Y, Wang F, Yan G, et al.
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MeSH
Acetyl Coenzyme AAmino Acids, Branched-ChainAnimalsCarcinoma, HepatocellularCarnitine O-PalmitoyltransferaseCell Line, TumorGene Expression Regulation, NeoplasticHumansLipid MetabolismLiver NeoplasmsMaleMiceMutationSignal TransductionTOR Serine-Threonine KinasesTumor Suppressor Protein p53Xenograft Model Antitumor Assays
DOI 10.1016/j.canlet.2024.217006
PMID 38823763
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