Increased adipocyte O2 consumption triggers HIF-1α, causing inflammation and insulin resistance in obesity.
Cell2014Lee YS, Kim JW, Osborne O, et al.
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MeSH
Adenine Nucleotide Translocator 2AdipocytesAnimalsBasic Helix-Loop-Helix ProteinsCell HypoxiaDiet, High-FatEndothelial PAS Domain-Containing Protein 1Fatty AcidsHypoxia-Inducible Factor 1, alpha SubunitInflammationInsulin ResistanceLactic AcidMiceMice, KnockoutNitric OxideObesityOxygen
DOI 10.1016/j.cell.2014.05.012
PMID 24906151
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