ATR-Chk1 pathway inhibition promotes apoptosis after UV treatment in primary human keratinocytes: potential basis for the UV protective effects of caffeine.
The Journal of investigative dermatology2009Heffernan TP, Kawasumi M, Blasina A, et al.
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MeSH
AdultAgedApoptosisAtaxia Telangiectasia Mutated ProteinsCaffeineCell Cycle ProteinsCells, CulturedCheckpoint Kinase 1DNA-Binding ProteinsEpidermal CellsFemaleHumansKeratinocytesPhosphodiesterase InhibitorsPhosphorylationProtein KinasesProtein Serine-Threonine KinasesRNA, Small InterferingTumor Suppressor Protein p53Tumor Suppressor ProteinsUltraviolet Rays