Antidepressant action of ketamine via mTOR is mediated by inhibition of nitrergic Rheb degradation.
Molecular psychiatry2016Harraz MM, Tyagi R, Cortés P, et al.
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MeSH
AnimalsAntidepressive AgentsCells, CulturedCerebral CortexCysteineDepressionDisease Models, AnimalEmbryo, MammalianExploratory BehaviorFemaleGene Expression RegulationHEK293 CellsHumansKetamineMaleMice, Inbred C57BLMice, KnockoutMonomeric GTP-Binding ProteinsN-MethylaspartateNeuronsNeuropeptidesNitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IIPregnancyProteolysisRas Homolog Enriched in Brain ProteinS-NitrosothiolsSignal TransductionSwimmingTOR Serine-Threonine KinasesTime Factors