Citrulline directly modulates muscle protein synthesis via the PI3K/MAPK/4E-BP1 pathway in a malnourished state: evidence from in vivo, ex vivo, and in vitro studies.
American journal of physiology. Endocrinology and metabolism2017Le Plénier S, Goron A, Sotiropoulos A, et al.
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MeSH
AndrostadienesAnimalsCarrier ProteinsChromonesCitrullineEnzyme InhibitorsFlavonoidsIn Vitro TechniquesIntracellular Signaling Peptides and ProteinsMaleMalnutritionMechanistic Target of Rapamycin Complex 1Mitogen-Activated Protein KinasesMorpholinesMultiprotein ComplexesMuscle Fibers, SkeletalMuscle ProteinsMuscle, SkeletalPhosphatidylinositol 3-KinasesPhosphoproteinsProtein Kinase InhibitorsProto-Oncogene Proteins c-aktRatsRats, Sprague-DawleySignal TransductionSirolimusTOR Serine-Threonine KinasesWortmannin
DOI 10.1152/ajpendo.00203.2016
PMID 27827806
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