Caffeine and the analog CGS 15943 inhibit cancer cell growth by targeting the phosphoinositide 3-kinase/Akt pathway.
Cancer biology & therapy2014Edling CE, Selvaggi F, Ghonaim R, et al.
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MeSH
Antineoplastic AgentsApoptosisCaffeineCarcinoma, HepatocellularCarcinoma, Pancreatic DuctalCell Line, TumorCell ProliferationHumansLiver NeoplasmsPancreatic NeoplasmsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktPurinergic P1 Receptor AgonistsQuinazolinesSignal TransductionTriazoles