TIPE2 gene transfer ameliorates aging-associated osteoarthritis in a progeria mouse model by reducing inflammation and cellular senescence.
Molecular therapy : the journal of the American Society of Gene Therapy2024Guo P, Gao X, Nelson AL, et al.
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MeSH
AgingAnimalsCartilage, ArticularCellular SenescenceChondrocytesDependovirusDisease Models, AnimalGene Transfer TechniquesGenetic TherapyGenetic VectorsHumansInflammationIntracellular Signaling Peptides and ProteinsMiceMice, KnockoutOsteoarthritisProgeriaTumor Necrosis Factor-alpha
DOI 10.1016/j.ymthe.2024.07.027
PMID 39095992
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